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Acneform eruptions and antitubercular drugs
R P Sharma1, A K Kothari, N K Sharma
1Departments of Dermatology and Tuberculosis & Chest Diseases, LLRM Medical College, Meerut 250 004, U.P., India, .
Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
Summary
Tuberculosis treatment can cause acneform eruptions in a small percentage of patients. Rifampicin was the most frequent cause, followed by Isoniazid and Ethambutol.
Area of Science:
- Dermatology
- Pharmacology
- Infectious Diseases
Background:
- Tuberculosis (TB) treatment commonly involves multi-drug regimens.
- Cutaneous adverse drug reactions are a concern in antitubercular therapy.
- Acneform eruptions are a known, though infrequent, side effect of some medications.
Purpose of the Study:
- To determine the incidence of acneform eruptions in patients undergoing antitubercular therapy.
- To identify specific antitubercular drugs associated with causing these skin reactions.
Main Methods:
- Retrospective analysis of 774 patient cases undergoing antitubercular therapy.
- Documentation of all reported adverse skin reactions, specifically acneform eruptions.
- Calculation of incidence rates for overall eruptions and by individual drug.
Main Results:
- A total of 11 out of 774 patients (1.42%) developed acneform eruptions.
- Rifampicin was associated with the highest incidence (1.48%).
- Isoniazid (0.53%) and Ethambutol (0.63%) also showed association with acneform eruptions.
Conclusions:
- Acneform eruptions are an uncommon adverse effect of standard antitubercular therapy.
- Rifampicin appears to be the most implicated drug in this cohort.
- Monitoring for dermatological side effects is important during tuberculosis treatment.
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