Related Experiment Videos

Pyoderma gangrenosum in childhood

M L Khatri1, M Shafi, M Benghazil

  • 1Department of Dermatology, Central Hospital and Faculty of Medicine, Al-Fatch University of Medical Sciences, Tripoli, Libya, .

Indian Journal of Dermatology, Venereology and Leprology
|October 19, 2010
PubMed

Insights

Pyoderma gangrenosum, a rare skin condition, can occur in infants and children. Dapsone therapy proved effective in most cases, suggesting it

Area of Science:

  • Dermatology
  • Pediatric Medicine

Background:

  • Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis.
  • While often associated with systemic diseases, PG can manifest in pediatric populations.

Purpose of the Study:

  • To describe clinical characteristics and treatment outcomes of pediatric PG cases.
  • To evaluate the efficacy of dapsone in treating pediatric PG.

Main Methods:

  • Retrospective case series of four pediatric patients diagnosed with PG.
  • Clinical presentation, disease course, and treatment responses were analyzed.

Main Results:

  • Patients presented with papulopustular or nodular lesions evolving into ulcers with characteristic undermined edges.
  • Three patients responded well to dapsone monotherapy; one required dapsone and prednisolone.
  • Antibiotic therapy was ineffective in all cases.

Conclusions:

  • Pyoderma gangrenosum is not exceedingly rare in infancy and childhood.
  • PG in pediatric patients may occur independently of systemic diseases.
  • Dapsone is an effective treatment option for pediatric PG.

Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Streptococcal Pharyngitis01:27

Streptococcal Pharyngitis

Streptococcal pharyngitis, commonly known as “strep throat,” is an acute infection of the oropharyngeal tissues caused by the Gram‑positive Group A Streptococcus (Streptococcus pyogenes). Transmission occurs primarily through respiratory droplets expelled during coughing, sneezing, or talking.Mechanisms of Host Entry and Immune EvasionUpon entering the host, S. pyogenes adheres to the mucosal epithelial cells of the pharynx via surface proteins, notably lipoteichoic acid and the antiphagocytic...