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PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
Published on: June 14, 2018
Nuclear neuroimaging in acute and subacute ischemic stroke
Naohiko Oku1, Toru Kashiwagi, Jun Hatazawa
1Nuclear Medicine and PET Center, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Japan. okun@hyo-med.ac.jp
Annals of Nuclear Medicine
|October 19, 2010
Summary
Neuroimaging techniques like SPECT and PET are crucial for identifying the ischemic penumbra in stroke patients. These methods help assess blood flow and metabolism, guiding reperfusion therapy and evaluating treatment effectiveness.
Area of Science:
- Nuclear medicine
- Neuroimaging
Background:
- Neuroimaging is a rapidly advancing field in nuclear medicine for ischemic stroke.
- Blood flow and metabolism measurements are established for acute ischemic stroke.
Purpose of the Study:
- To highlight the role of neuroimaging in identifying the ischemic penumbra.
- To discuss the application of various imaging techniques in different phases of ischemic stroke.
- To explore the potential of imaging as a marker for therapeutic efficacy.
Main Methods:
- Perfusion imaging, central-type benzodiazepine receptor imaging, and hypoxy imaging for ischemic penumbra.
- Peripheral-type benzodiazepine receptor imaging and annexin V imaging for subacute stroke inflammation and apoptosis.
Main Results:
- Neuroimaging can visualize the ischemic penumbra and cellular responses.
- These techniques aid in excluding risky patients for reperfusion therapy beyond initial hours.
- Imaging markers can potentially evaluate drug and intervention effects.
Conclusions:
- Neuroimaging is vital for assessing ischemic stroke, particularly for identifying the penumbra.
- It aids in guiding reperfusion therapy and evaluating treatment efficacy.
- Future therapeutic regimens may benefit from imaging-based efficacy markers.
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