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Updated: Jun 8, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Fluid overload and acute kidney injury
Preethi Yerram1, Poorna R Karuparthi, Madhukar Misra
1Department of Internal Medicine, Division of Nephrology, University of Missouri-Columbia, Columbia, Missouri, USA.
Hemodialysis International. International Symposium on Home Hemodialysis
|October 20, 2010
Summary
Fluid overload worsens outcomes in critically ill patients with acute kidney injury (AKI). Management involves guided resuscitation, fluid status assessment, and early renal replacement therapy for neutral or negative fluid balance.
Area of Science:
- Nephrology
- Critical Care Medicine
- Fluid Physiology
Background:
- Acute kidney injury (AKI) is prevalent in critically ill patients, correlating with poorer prognoses.
- Fluid therapy is crucial but can lead to fluid overload, particularly in septic AKI.
- Growing evidence links fluid overload to adverse outcomes in this patient population.
Purpose of the Study:
- To review the pathophysiological relationship between fluid overload and AKI.
- To explore mechanisms of organ dysfunction resulting from fluid overload.
- To outline management strategies for fluid overload in AKI.
Main Methods:
- Literature review focusing on fluid overload and acute kidney injury.
- Analysis of pathophysiological links and organ dysfunction mechanisms.
- Synthesis of current management strategies and recommendations.
Main Results:
- Fluid overload is increasingly recognized as a detrimental factor in AKI.
- Specific mechanisms linking fluid overload to organ dysfunction are elucidated.
- Evidence supports a management approach emphasizing fluid balance.
Conclusions:
- Fluid overload significantly impacts AKI outcomes in critically ill patients.
- A proactive management strategy including fluid assessment and timely renal replacement therapy is essential.
- Aiming for neutral or negative fluid balance is a key therapeutic goal.
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