[Detection of micro-vascular density(MVD) and its clinical significance in lung cancer]

To study the relationship between MVD of lung cancer tissues and the pathophysiological characteristics and prognosis in patients with lung cancer.

The MVD was detected in 114 lung cancer tissues, 30 benign pulmonary tissues by immunohistochemical staining (LSAB method).

MVD in lung cancer tissues (30.47+/-10.56) was significantly higher than that in benign pulmonary tissues (10.23+/-6.92)(P<0.01); The MVD was closely related to the size of primary cancer, lymph node status, P-TNM stages, grade of cell differentiation of lung cancer (P<0.01), but not to the histological classification and site of the cancer, and age, sex and smoking or not in the patients with lung cancer (P<0.05); The 5-year survival rate in patients (17.27%) with high MVD (>=30) was significantly lower than that in patients (52.74%) with low MVD (<30)(P<0.01); The survival time of patients with lung cancer was negatively related to MVD (r=-0.521,P<0.01); The results of multivariable COX model showed that the P-TNM and MVD were the most significant variables for predicting prognosis among the all related factors in lung cancer.

Increase of MVD may play an important role in the oncogenesis, development, metastasis of lung cancer and might be served as a tumor marker to evaluate the biological behavior of lung cancer. Detection of MVD might be helpful to predict prognosis and guide the postoperative multi-modality therapy in patients with lung cancer.