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Subacute cutaneous lupus erythematosus exacerbated or induced by chemotherapy
Alisa A Funke1, Carol L Kulp-Shorten, Jeffrey P Callen
1Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA. alisa.funke@ucdenver.edu
Background:
Subacute cutaneous lupus erythematosus (SCLE), characterized by nonscarring, photodistributed, annular or papulosquamous plaques, is occasionally induced by medication. It has been strongly associated with antihypertensive medications and terbinafine hydrochloride.
Observation:
We describe 3 women with breast cancer who developed SCLE-like eruptions after being administered doxorubicin hydrochloride and cyclophosphamide. Biopsy specimens of all 3 patients demonstrated an interface dermatitis. Treatment consisted of topical and/or systemic corticosteroids, photoprotection, and switching the chemotherapeutic regimens.
Conclusions:
Based on clinicopathologic correlation and timing of chemotherapy exposure, the patients were believed to have drug-induced SCLE. Although cutaneous eruption, pruritus, and photosensitivity are known adverse effects of doxorubicin, to our knowledge there has been only 1 previously reported case of doxorubicin-induced SCLE.
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