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Updated: Jun 7, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

[Primary and secondary hypocholesterolemia].

Jun-xian Song¹, Jing-yi Ren, Hong Chen

¹Department of Cardiology, Peking University People's Hospital, Beijing 100044, China.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences

|October 20, 2010

Summary

This summary is machine-generated.

Hypocholesterolemia, or low cholesterol, is often overlooked but can signal serious health issues. Recognizing its causes and consequences is crucial for patient well-being.

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LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

Area of Science:

Endocrinology
Metabolic Disorders
Clinical Medicine

Context:

Hypocholesterolemia is defined as serum total cholesterol below the 5th percentile for age and sex.
It is frequently overlooked in clinical practice compared to hypercholesterolemia.
This condition is a common dyslipidemia, often stemming from secondary factors.

Purpose:

To highlight the clinical significance of hypocholesterolemia.
To review the diverse causes of hypocholesterolemia, both primary and secondary.
To underscore the adverse health outcomes associated with low cholesterol levels.

Summary:

Primary causes include genetic disorders affecting cholesterol metabolism (e.g., abetalipoproteinemia, Tangier disease).
Secondary causes encompass conditions like anemia, hyperthyroidism, malignancy, liver disease, critical illness, infections, and certain medications.
Adverse events linked to hypocholesterolemia include increased mortality, intracerebral hemorrhage, cancer, infections, adrenal failure, suicide, and mental disorders.

Impact:

Increased awareness among physicians regarding hypocholesterolemia is necessary.
The rise of intensive lipid-lowering therapies necessitates greater attention to low cholesterol levels.
Early recognition and management of hypocholesterolemia can potentially mitigate severe health consequences.