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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: Jun 7, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Brain imaging in migraine research.

David Borsook1, Richard Hargreaves

  • 1From P.a.i.n. Group, Massachusetts General Hospital, Boston, MA, USA.

Headache
|October 21, 2010
PubMed
Summary
This summary is machine-generated.

Understanding migraine requires studying its pathophysiology and pharmacology. Advanced imaging techniques help identify brain targets for effective migraine treatments and understand patient response variability.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Medical Imaging

Background:

  • Migraine understanding relies on clinical observation, experimental medicine, and studying anti-migraine agents.
  • Functional brain imaging complements observational studies by highlighting brain pathways involved in migraine predisposition and pain modulation.
  • Molecular imaging visualizes drug targets in the brain, aiding drug discovery and candidate evaluation.

Purpose of the Study:

  • To advance the understanding of migraine pathophysiology and pharmacology.
  • To explore the role of functional and molecular imaging in migraine research and drug discovery.
  • To investigate brain alterations in episodic and chronic migraine for improved therapeutic strategies.

Main Methods:

  • Utilizing functional brain imaging to study migraine phenotypes and identify relevant brain pathways.
  • Employing molecular imaging to visualize and confirm engagement of migraine drug targets in the brain.
  • Analyzing brain states during episodic (interictal and ictal) and chronic migraine.

Main Results:

  • Significant progress in identifying brain pathways involved in migraine predisposition and pain modulation.
  • Demonstrated utility of molecular imaging in evaluating drug candidate engagement with targets.
  • Highlighted the progressive nature of migraine and its impact on therapeutic responsiveness.

Conclusions:

  • Advanced imaging techniques are crucial for understanding migraine pathophysiology and pharmacology.
  • Molecular imaging facilitates the selection and evaluation of novel anti-migraine therapeutics.
  • Further research into brain alterations in migraine is essential for personalized treatment approaches.