Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Immune biomarkers, profiles, and responses: a vaccine ontology perspective.

Journal of biomedical semantics·2026

Same author

Towards Healthy Aging through Semantic Enrichment.

CEUR workshop proceedings.·2026

Same author

Vaxjo 2.0: An ontology- and large language model-powered knowledge base of vaccine adjuvants and mechanisms.

Frontiers in cellular and infection microbiology·2026

Same author

Profiling of human lung and gut microbiomes in different conditions of chronic obstructive pulmonary disease using ontology-based evidence synthesis and reasoning.

Frontiers in cellular and infection microbiology·2026

Same author

BERTopic-driven term extraction from biomedical texts toward ontology population: evaluating vaccine ontology with Plotkin's vaccines corpus.

Journal of biomedical semantics·2026

Same author

VO: The Vaccine Ontology.

Scientific data·2026

Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026

Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026

Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026

Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026

Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026

Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 7, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

Protegen: a web-based protective antigen database and analysis system.

Brian Yang¹, Samantha Sayers, Zuoshuang Xiang

¹Unit for Laboratory Animal Medicine, University of Michigan Medical School, Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.

Nucleic Acids Research

|October 21, 2010

Summary

This summary is machine-generated.

Protegen is a new database for protective antigens, crucial for vaccine development and disease diagnosis. It centralizes curated data and offers analysis tools for researchers studying host immunity.

More Related Videos

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Related Experiment Videos

Last Updated: Jun 7, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Area of Science:

Immunology
Bioinformatics
Vaccinology

Background:

Protective antigens are key targets for acquired immunity, essential for vaccine development, disease diagnosis, and understanding host immune responses.
Current research lacks a centralized resource for comprehensive protective antigen data and analysis.

Purpose of the Study:

To develop Protegen, a web-based database and analysis system for protective antigens.
To curate and store information on protective antigens, including experimental evidence and bioinformatics data.
To provide tools for searching, analyzing, and exchanging protective antigen data.

Main Methods:

Curating basic antigen information and experimental evidence from peer-reviewed literature.
Automatically extracting detailed gene/protein data from existing databases using custom scripts.
Employing bioinformatics tools to compute antigen features like molecular weight, pI, and subcellular localization.
Developing a user-friendly web interface for querying and visualizing data, including a BLAST search functionality.

Main Results:

Protegen currently contains 590 protective antigens against over 100 infectious and non-infectious diseases.
The database integrates curated information with automatically extracted gene/protein data.
A functional web interface with search and BLAST capabilities is available.
Data is stored using the Vaccine Ontology (VO) in OWL format and exportable to FASTA and Excel.

Conclusions:

Protegen serves as a valuable, centralized resource for protective antigen research.
The database facilitates vaccine development, disease diagnostics, and fundamental immunology studies.
Protegen's integrated data and analysis tools enhance the study of host immunity.