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[Effects of magnesium pidolate on cardiovascular hemodynamics]
G Destro1, P Marino, E Barbieri
1Divisione Clinicizzata di Cardiologia, Università degli Studi, Verona.
Cardiologia (Rome, Italy)
|December 1, 1990
Summary
Magnesium (Mg) reduces left ventricular pressure in ischemic heart disease patients by lowering aortic pressure. This improves ventricular filling and active relaxation without affecting passive diastolic properties.
Area of Science:
- Cardiology
- Cardiovascular Physiology
- Pharmacology
Background:
- Ischemic heart disease poses significant cardiovascular risks.
- Magnesium's role in cardiovascular function is under investigation.
- Understanding magnesium's hemodynamic effects is crucial for therapeutic applications.
Purpose of the Study:
- To determine the hemodynamic effects of magnesium (Mg) in patients with ischemic heart disease.
- To evaluate the impact of intravenous Mg pidolate on left ventricular function.
- To assess changes in cardiac output, pressures, and diastolic properties.
Main Methods:
- Ten patients with ischemic heart disease received 1g of Mg pidolate intravenously over 3 minutes.
- Hemodynamic parameters were measured using micromanometer catheter and echocardiography.
- Data collection occurred before and at intervals (3, 5, 8 minutes) after Mg administration.
Main Results:
- At 5 minutes, Mg significantly reduced left ventricular peak systolic pressure (p=0.015).
- Early diastolic filling (E wave) was augmented (p=0.013), and cardiac output slightly increased (p=0.092).
- Active relaxation improved, while passive diastolic properties remained unaffected.
Conclusions:
- Magnesium unloads the ischemic left ventricle by reducing systemic aortic pressure.
- Secondary increase in early filling is observed, potentially due to improved ventricular emptying.
- Mg enhances active relaxation, with no significant impact on passive diastolic properties in this context.