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A model for harmonizing flow cytometry in clinical trials

Holden T Maecker1, J Philip McCoy,

  • 1Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA. maecker@stanford.edu

Nature Immunology
|October 21, 2010
PubMed

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Flow Cytometry01:23

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...