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Fungal cyclooligomer depsipeptides: from classical biochemistry to combinatorial biosynthesis
Roderich Süssmuth1, Jane Müller, Hans von Döhren
1Technische Universität Berlin, Institut für Chemie, Berlin, Germany. suessmuth@chem.tu-berlin.de
Natural Product Reports
|October 21, 2010
Summary
This review explores fungal cyclooligomer depsipeptides, detailing their biological activities and complex biosynthesis. It highlights how combinatorial methods diversify these important fungal compounds.
Area of Science:
- Mycology
- Natural Product Chemistry
- Biochemistry
Background:
- Fungal cyclooligomer depsipeptides are a class of complex natural products.
- These compounds exhibit diverse biological activities.
- Understanding their biosynthesis is crucial for natural product drug discovery.
Purpose of the Study:
- To review the known biological activities of fungal cyclooligomer depsipeptides.
- To elucidate the iterative and recursive biosynthetic mechanisms involved in their formation.
- To explore methods for structural diversification using combinatorial biosynthesis.
Main Methods:
- Literature review of published research on fungal cyclooligomer depsipeptides.
- Analysis of biosynthetic pathways and enzymatic machinery.
- Examination of combinatorial biosynthetic strategies and their outcomes.
Main Results:
- Fungal cyclooligomer depsipeptides display a wide range of pharmacological properties.
- Complex iterative and recursive enzymatic processes govern their assembly.
- Combinatorial biosynthesis offers powerful tools for generating novel structural analogs.
Conclusions:
- Fungal cyclooligomer depsipeptides represent a promising source of bioactive natural products.
- Further investigation into their biosynthesis can unlock new chemical diversity.
- Targeted biosynthetic engineering holds potential for developing novel therapeutics.
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