Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Introduction to Lymphatic and Immune System01:23

Introduction to Lymphatic and Immune System

Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antihistamines Increase Body Mass Index Percentiles and Z-Scores in Hispanic Children.

Children (Basel, Switzerland)·2020
Same author

Emerging Roles of Mast Cells in the Regulation of Lymphatic Immuno-Physiology.

Frontiers in immunology·2020
Same author

Histamine-mediated autocrine signaling in mesenteric perilymphatic mast cells.

American journal of physiology. Regulatory, integrative and comparative physiology·2020
Same author

Lymphatic Cannulation for Lymph Sampling and Molecular Delivery.

Journal of immunology (Baltimore, Md. : 1950)·2019
Same author

Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.

Hepatology (Baltimore, Md.)·2019
Same author

Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome.

American journal of physiology. Gastrointestinal and liver physiology·2018

Related Experiment Video

Updated: Jun 7, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

Basic mechanisms controlling lymph transport in the mesenteric lymphatic net.

Anatoliy A Gashev1

  • 1Department of Systems Biology and Translational Medicine, Cardiovascular Research Institute, Division of Lymphatic Biology, College of Medicine, Texas A&M Health Science Center, Temple, Texas 76504, USA. gashev@tamu.edu

Annals of the New York Academy of Sciences
|October 22, 2010
PubMed
Summary

Lymphatic vessels in the digestive system have intrinsic and extrinsic pumps and flows. Age-related changes may impair lymph transport function, impacting homeostasis and lipid absorption.

More Related Videos

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
13:17

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

Published on: March 6, 2015

Real-time Evaluation of Absolute, Cytosolic, Free Ca2+ and Corresponding Contractility in Isolated, Pressurized Lymph Vessels
08:46

Real-time Evaluation of Absolute, Cytosolic, Free Ca2+ and Corresponding Contractility in Isolated, Pressurized Lymph Vessels

Published on: March 22, 2024

Related Experiment Videos

Last Updated: Jun 7, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
13:17

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

Published on: March 6, 2015

Real-time Evaluation of Absolute, Cytosolic, Free Ca2+ and Corresponding Contractility in Isolated, Pressurized Lymph Vessels
08:46

Real-time Evaluation of Absolute, Cytosolic, Free Ca2+ and Corresponding Contractility in Isolated, Pressurized Lymph Vessels

Published on: March 22, 2024

Area of Science:

  • Digestive System Physiology
  • Lymphatic Vascular Biology
  • Homeostasis and Transport Mechanisms

Background:

  • Lymphatic vessels are crucial for fluid and macromolecular transport in the digestive system.
  • Understanding lymph transport in mesenteric lymphatic vessels is vital for digestive health.
  • Age-related changes can affect the structure and function of these vessels.

Purpose of the Study:

  • To review concepts of lymph transport in mesenteric lymphatic vessels.
  • To discuss age-related alterations impacting lymph flow.
  • To highlight the necessity of advancing knowledge in lymphatic vessel function.

Main Methods:

  • Summary of an oral presentation at a workshop.
  • Discussion of extrinsic and intrinsic pumps and flows.
  • Consideration of age-related structural and regulatory changes.

Main Results:

  • Lymph transport involves complex intrinsic and extrinsic mechanisms.
  • Age-related alterations in mesenteric lymphatics may lead to functional decline.
  • Modern experimental tools offer new avenues for research.

Conclusions:

  • Lymphatic vessel function is essential for maintaining homeostasis.
  • Impaired lymph transport can affect lipid absorption and immune cell trafficking.
  • Further research is needed to fully understand lymphatic roles in the digestive system.