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Related Experiment Video

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Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

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Published on: October 7, 2021

When neurogenesis encounters aging and disease.

Orly Lazarov¹, Mark P Mattson, Daniel A Peterson

¹Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA. olazarov@uic.edu

Trends in Neurosciences

|October 22, 2010

Summary

Reduced neurogenesis contributes to cognitive decline in aging and Alzheimer's disease (AD). Strategies like exercise and stem cell therapies may preserve brain function by enhancing neurogenesis.

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Area of Science:

Neuroscience
Cell Biology
Gerontology

Background:

Aging and Alzheimer's disease (AD) are associated with cognitive deficits.
Reduced neurogenesis is a potential underlying factor in these cognitive impairments.

Purpose of the Study:

To review the evidence linking reduced neurogenesis to age-related cognitive decline and AD.
To discuss molecular and cellular mechanisms of impaired neurogenesis in the aging brain.
To explore therapeutic strategies for enhancing neurogenesis and preserving cognitive function.

Main Methods:

Literature review of studies on neurogenesis, aging, and Alzheimer's disease.
Analysis of molecular and cellular alterations affecting neurogenesis.
Evaluation of factors influencing neurogenesis and cognitive function.

Main Results:

Impaired neurogenesis is implicated in age-related cognitive deficits and AD.
Molecular factors like presenilin-1 dysfunction, amyloid precursor protein misprocessing, hyperphosphorylated tau, and beta-amyloid contribute to impaired neurogenesis in AD.
Lifestyle factors (exercise, environmental enrichment, dietary restriction) and stem cell interventions show promise for enhancing neurogenesis.

Conclusions:

Understanding neurogenic signaling pathways is crucial for developing therapies against cognitive decline.
Interventions targeting neurogenesis, including lifestyle changes and stem cell therapies, offer potential strategies for brain health preservation.