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Picoinjection of Microfluidic Drops Without Metal Electrodes

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High-throughput injection with microfluidics using picoinjectors.

Adam R Abate¹, Tony Hung, Pascaline Mary

¹School of Engineering and Applied Sciences and Department of Physics, Harvard University, Cambridge, MA 02138, USA.

Proceedings of the National Academy of Sciences of the United States of America

|October 22, 2010

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A new picoinjector device enables precise reagent addition in droplet microfluidics using electro-microfluidics. This robust technology achieves kilohertz rates for efficient serial and combinatorial additions.

Area of Science:

Microfluidics
Electrokinetics
Biotechnology

Background:

Precise reagent addition is crucial for droplet-based microfluidic systems.
Existing methods lack robustness and high throughput for reagent delivery.

Purpose of the Study:

To introduce a novel device, the picoinjector, for controlled reagent addition in microfluidic systems.
To demonstrate the device's capability for high-throughput and versatile reagent delivery.

Main Methods:

Development of a picoinjector utilizing electro-microfluidics.
Characterization of reagent addition volumes and rates.
Demonstration of serial and combinatorial addition capabilities.

Main Results:

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The picoinjector provides robust and controlled reagent addition.

The device operates at kilohertz rates, enabling high-throughput applications.

Multiple injections for serial and combinatorial additions were successfully performed.

Conclusions:

The picoinjector offers a robust solution for reagent addition in droplet microfluidics.
This technology significantly advances the capabilities of microfluidic systems for various applications.
The device facilitates high-speed, precise, and versatile reagent handling.