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Updated: Jun 7, 2026
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A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Direct carbon-carbon bond formation via soft enolization: aldol addition of α-halogenated thioesters
Julianne M Yost1, Rachel J Alfie, Emily M Tarsis
1Department of Chemistry, Duke University, Durham, NC, USA.
Chemical Communications (Cambridge, England)
|October 22, 2010
Abstract:
α-Halo thioesters undergo soft enolization and syn-selective direct aldol addition to aldehydes in the presence of MgBr(2)·OEt(2) and i-Pr(2)NEt to produce α-halo-β-hydroxy thioesters.
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01:33Aldol Condensation vs Claisen Condensation
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