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Monitoring endocrine function in males: using intra-atrial cannulas to monitor plasma hormonal dynamics in toxicology
Patricia A Fail1, Stephanie A Anderson
1Research Triangle Institute, Research Triangle Park, North Carolina, USA.
Abstract:
Intra-atrial cannulation provides assessment of endocrine change within animals. Protocols for permanent tethers used in short-term 5- to 10-day experiments and permanent vascular access used in long-term (>10 days) experiments are presented. A protocol for blood processing is also included. Data from a longitudinal endocrine baseline assessment (LEBA) and an endocrine challenge test (ECT) are presented as well.
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