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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Blastomycosis-like pyoderma: response to systemic retinoid therapy.

Kathy B Kobraei¹, Stanton K Wesson

¹Division of Dermatology, University of Florida, Gainesville, Florida 32610, USA. kathy.kobraei@medicine.ufl.edu

International Journal of Dermatology

|October 23, 2010

Summary

Blastomycosis-like pyoderma, a skin condition mimicking other disorders, can occur in immunocompromised patients. Oral acitretin effectively treated a case in a patient with thyroid cancer undergoing sorafenib therapy.

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Area of Science:

Dermatology
Oncology

Background:

Blastomycosis-like pyoderma presents as a proliferative skin response with diverse causes.
It often affects sun-damaged skin in immunocompromised individuals.
This condition can be mistaken for inflammatory or neoplastic skin diseases.

Observation:

A patient with metastatic medullary thyroid carcinoma, treated with sorafenib, developed blastomycosis-like pyoderma.
Previous treatments for the skin condition were ineffective.

Findings:

The patient's blastomycosis-like pyoderma showed significant improvement with oral acitretin treatment.
Acitretin, a retinoid, demonstrated efficacy in this challenging case.

Implications:

This case highlights a potential treatment option for blastomycosis-like pyoderma in complex patient populations.
It suggests a role for acitretin in managing this rare skin condition, particularly in patients with underlying malignancies and those on targeted therapies like sorafenib.