Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sphingosine-1-phosphate cross-talks to Notch via a S1PR1-Dll4-MPDZ complex to regulate endothelial barrier function.

bioRxiv : the preprint server for biology·2026
Same author

Electrical Stimulation Directs Formation of Perfused Vasculature in Engineered Tissues.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

A 3D In Vitro Model of the Human Hepatobiliary Junction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Synthetic control of implanted engineered liver tissue growth.

Science advances·2026
Same author

A 3D microfluidic model of exchange between perfused blood and lymphatic microvascular networks.

Lab on a chip·2026
Same author

Leveraging Kinase Drugs for Neurosciences: Discovery of Selective, CNS-Penetrant Reversible Bruton's Tyrosine Kinase Inhibitors as Therapeutics for Neuroinflammation.

Journal of medicinal chemistry·2026

Related Experiment Video

Updated: Jun 7, 2026

Sandwich-like Microenvironments to Harness Cell/Material Interactions
06:50

Sandwich-like Microenvironments to Harness Cell/Material Interactions

Published on: August 4, 2015

Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and

Colin K Choi1, Mark T Breckenridge, Christopher S Chen

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

Trends in Cell Biology
|October 23, 2010
PubMed
Summary

Cells sense their environment through complex adhesion interactions. Advances in biomaterials offer new ways to study these cell adhesion functions and the cellular microenvironment.

More Related Videos

BioMEMS: Forging New Collaborations Between Biologists and Engineers
07:26

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
10:28

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

Related Experiment Videos

Last Updated: Jun 7, 2026

Sandwich-like Microenvironments to Harness Cell/Material Interactions
06:50

Sandwich-like Microenvironments to Harness Cell/Material Interactions

Published on: August 4, 2015

BioMEMS: Forging New Collaborations Between Biologists and Engineers
07:26

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
10:28

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Biophysics

Background:

  • Cells dynamically interact with their microenvironment, responding to diverse external cues.
  • Understanding how cells sense and respond to the extracellular matrix and neighboring cells is crucial but challenging due to complex adhesive interactions.
  • The cellular microenvironment significantly influences cell behavior and function.

Purpose of the Study:

  • To review major approaches for studying adhesion-mediated cell functions.
  • To highlight advancements in biocompatible materials for investigating cell adhesion.
  • To discuss future directions in understanding the cellular microenvironment's role in cell signaling.

Main Methods:

  • Review of engineering approaches for biocompatible materials.
  • Analysis of techniques for studying adhesion-mediated cell functions.
  • Discussion of insights gained from material-based cell studies.

Main Results:

  • Biocompatible materials have enabled novel methods to probe cell adhesion.
  • Significant progress has been made in understanding the role of the cellular microenvironment.
  • Adhesion interactions are key to how cells sense and respond to their surroundings.

Conclusions:

  • Engineering biocompatible materials is pivotal for advancing cell adhesion research.
  • Further development of these materials will deepen our understanding of cell-environment interactions.
  • Future research should focus on leveraging material innovations to explore complex cell signaling pathways.