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Updated: May 23, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
[Correlation between PTPN22 gene polymorphism and systemic lupus erythematosus in Chinese Han patients]
1Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. pengxb@fimmu.com
Objective:
To investigate the association between 1858C/T single nucleotide polymorphism on exon 14 of the protein tyrosine phosphatase nonreceptor-22 (PTPN22) gene and systemic lupus erythematosus in Chinese Han patients.
Methods:
Forty Chinese Han patients with SLE and 20 normal control subjects were enrolled in the study, and PTPN22 gene 1858 C/T polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results:
No significant difference was found in the CC, CT, and TT genotype frequencies or in the C and T allele frequencies between the SLE patients and the normal controls.
Conclusion:
1858C/T on PTPN22 gene might not be associated with the susceptibility of SLE in Chinese Han population.
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