ESHRE PGD consortium best practice guidelines for fluorescence in situ hybridization-based PGD

Area of Science:

• Reproductive Medicine
• Clinical Genetics

Background:

• ESHRE's 2005 PGD guidelines required updating due to new technologies and evolving practices.
• Recent ESHRE advice necessitated a revision of how practice guidelines are formulated.
• The updated guidelines are now divided into four separate documents covering different PGD aspects.

Purpose of the Study:

• To revise and update the sections of the ESHRE PGD guidelines pertaining to fluorescence in situ hybridization (FISH)-based testing.
• To incorporate preimplantation genetic screening (PGS) into the guidelines, acknowledging its controversial nature and varied clinical opinions.
• To provide comprehensive guidance for developing optimal laboratory and clinical practices in PGD/PGS.

Main Methods:

• Focused update on FISH-based PGD testing sections within the revised ESHRE guidelines.
• Inclusion of preimplantation genetic screening (PGS) after considering opinions from laboratory specialists and clinicians.
• Comprehensive review of topics relevant to FISH-based PGD and PGS.

Main Results:

• Updated guidelines now address FISH-based PGD testing in detail.
• Preimplantation genetic screening (PGS) is included, reflecting ongoing debate and clinical interest.
• The guidelines cover a wide range of PGD/PGS practices, from referrals to quality assurance.

Conclusions:

• The revised ESHRE guidelines offer updated best practices for FISH-based PGD.
• The inclusion of PGS acknowledges its controversial yet relevant role in the field.
• These guidelines aim to support professionals in establishing high-quality PGD/PGS services.