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Related Experiment Video

Updated: Jun 7, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

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Precursors for late preterm birth in singleton gestations.

S Katherine Laughon1, Uma M Reddy, Liping Sun

  • 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland laughonsk@mail.nih.gov, USA.

Obstetrics and Gynecology
|October 23, 2010
PubMed
Summary

Many late preterm births are avoidable. Elective deliveries before 39 weeks increase neonatal morbidity and mortality risks, suggesting these should be postponed.

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Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Perinatal Epidemiology

Background:

  • Late preterm birth (34-36 weeks) is common and associated with increased neonatal morbidity.
  • Understanding the precursors and outcomes of late preterm birth is crucial for improving neonatal care.

Purpose of the Study:

  • To characterize the precursors of late preterm birth in singleton gestations.
  • To determine the incidences of neonatal morbidities and perinatal mortality based on gestational age and delivery precursor.

Main Methods:

  • Retrospective observational study comparing 15,136 late preterm births with 170,593 term deliveries.
  • Precursors categorized as spontaneous labor, preterm premature rupture of membranes (PROM), indicated delivery, or unknown.
  • Neonatal morbidities analyzed by precursor type and gestational age; potentially avoidable deliveries compared to term births.

Main Results:

  • Late preterm births constituted 7.8% of all births and 65.7% of preterm births.
  • Precursors included spontaneous labor (29.8%), preterm PROM (32.3%), indicated delivery (31.8%), and unknown (6.1%).
  • Neonatal morbidity and mortality increased in neonates born late preterm due to elective or "soft" precursors compared to term births.

Conclusions:

  • A substantial proportion of late preterm births are potentially avoidable.
  • Elective deliveries before 39 weeks of gestation are associated with increased risks and should be postponed.