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Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...

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Related Experiment Video

Updated: Jun 7, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

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Methacholine-induced lung function changes measured with infant body plethysmography.

L Pekka Malmberg1, Lauri von Wright, Anne Kotaniemi-Syrjänen

  • 1Department of Allergy, Helsinki University Central Hospital, Helsinki, Finland. pekka.malmberg@hus.fi

Pediatric Pulmonology
|October 23, 2010
PubMed
Summary

In infants, maximum forced expiratory flow (V'(maxFRC)) and specific airway conductance (sG(aw)) correlate during bronchoconstriction but are not interchangeable. V'(maxFRC) is more sensitive for detecting airway obstruction.

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Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
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Published on: July 10, 2018

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Physiology
  • Diagnostic Methods in Infants

Background:

  • Limited data exist on lung function changes using body plethysmography during induced bronchoconstriction in infants.
  • Assessing airway responsiveness (AR) in infants presents unique challenges.

Purpose of the Study:

  • To compare V'(maxFRC) from rapid thoracoabdominal compression (RTC) with plethysmographic sG(aw) during methacholine challenge.
  • To investigate functional residual capacity (FRC) changes during induced bronchoconstriction in infants.

Main Methods:

  • 94 infants with recurrent airway symptoms underwent methacholine airway challenge.
  • Measurements included RTC for V'(maxFRC) and body plethysmography for sG(aw) and FRC.

Main Results:

  • A significant association was found between changes in V'(maxFRC) and sG(aw), but agreement was poor.
  • V'(maxFRC) changes correlated better with oxygen saturation and were more sensitive to obstruction than sG(aw).
  • Methacholine challenge caused a significant increase in FRC alongside decreasing V'(maxFRC).

Conclusions:

  • Plethysmographic sG(aw) and V'(maxFRC) correlate but are not interchangeable for assessing infant airway obstruction.
  • V'(maxFRC) is more sensitive than sG(aw), but increased FRC during challenge may impact V'(maxFRC) validity.