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Related Experiment Video

Updated: Jun 7, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Microbubbles loaded with nanoparticles: a route to multiple imaging modalities.

Jai Il Park1, Dinesh Jagadeesan, Ross Williams

  • 1Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, ON, M5S3H6 Canada.

ACS Nano
|October 26, 2010
PubMed
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Researchers developed a novel method to create tiny, stable nanoparticles-functionalized bubbles. This technique enables versatile applications in medical imaging, offering enhanced diagnostic capabilities.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Microfluidics

Background:

  • Microbubbles are crucial for medical imaging and drug delivery.
  • Current methods for functionalizing microbubbles are often complex and multi-step.
  • Developing stable, functionalized bubbles is essential for advanced biomedical applications.

Purpose of the Study:

  • To develop a single-step method for producing small, stable, nanoparticle-functionalized bubbles.
  • To investigate the mechanism of bubble formation and nanoparticle functionalization.
  • To demonstrate the potential applications of these functionalized bubbles in medical imaging.

Main Methods:

  • Microfluidic generation of bubbles using a mixture of carbon dioxide and low-solubility gases.
  • Utilizing an aqueous solution containing protein, polysaccharide, and anionic nanoparticles.

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Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers
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Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers

Published on: January 24, 2025

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Last Updated: Jun 7, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
06:02

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers
10:40

Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers

Published on: January 24, 2025

  • Observing CO(2) dissolution, bubble shrinkage, and co-deposition of biopolymers and nanoparticles at the bubble interface.

    • Main Results:

    • Successfully produced microbubbles with a narrow size distribution and long-term stability.
    • Achieved functionalization with various nanoparticles (metal oxide, metal, semiconductor) on the bubble surface.
    • Demonstrated the potential of these bubbles for ultrasound and magnetic resonance imaging.

    Conclusions:

    • The single-step microfluidic approach offers an efficient way to create versatile, nanoparticle-functionalized bubbles.
    • These functionalized bubbles exhibit desirable properties for biomedical applications, particularly in advanced imaging.
    • This method provides a foundation for developing novel contrast agents and targeted delivery systems.