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Related Experiment Videos

Evaluation of methyl cellulose as controlled release matrix material.

K S Aithal1, A R Aroor, Y V Pathak

  • 1Kasturba Medical College, Manipal.

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
|April 1, 1990
PubMed
Summary

A new chewable tablet formulation using Methyl cellulose offers controlled release of sodium fluoride (NaF) for dental caries prevention. The optimal 30% Methyl cellulose concentration ensures ideal drug release, which is diffusion-controlled.

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Clinical evaluation of sodium flouride chewable tablets in dental caries.

Indian journal of dental research : official publication of Indian Society for Dental Research·2000

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Dental Research

Background:

  • Dental caries remains a significant public health concern.
  • Effective fluoride delivery systems are crucial for caries prevention.
  • Controlled-release formulations can improve therapeutic efficacy and patient compliance.

Purpose of the Study:

  • To develop a novel chewable tablet formulation for controlled sodium fluoride (NaF) release.
  • To investigate the impact of Methyl cellulose concentration on tablet properties and drug release kinetics.
  • To assess the suitability of the formulation for dental caries prevention.

Main Methods:

  • Formulation of chewable NaF tablets using varying concentrations of Methyl cellulose as a matrix.
  • Micromeritic analysis of granules and tablets.

Related Experiment Videos

  • In vitro dissolution studies conducted in distilled water at 37°C.
  • Analysis of drug release kinetics using Higuchi's equation.

    • Main Results:

    • Tablet and granule characteristics varied significantly with Methyl cellulose concentration.
    • The 30% Methyl cellulose concentration demonstrated the highest T80% (time for 80% drug release), indicating ideal controlled release.
    • In vitro drug release followed diffusion-controlled kinetics, adhering to the Higuchi model.
    • The fraction of drug released was proportional to the square root of time (t½).

    Conclusions:

    • A stable and effective chewable NaF tablet formulation for controlled release was successfully developed.
    • Methyl cellulose at 30% concentration is optimal for achieving sustained NaF release, suitable for dental caries prevention.
    • The diffusion-controlled release mechanism suggests predictable and consistent drug delivery.
    • Preliminary clinical studies show encouraging results, warranting further investigation.