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Criteria to indicate testosterone administration.

A T Kicman1, R V Brooks, S C Collyer

  • 1Drug Control and Teaching Centre, King's College, London University.

British Journal of Sports Medicine
|December 1, 1990
PubMed
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Detecting testosterone administration is possible using urinary testosterone/epitestosterone (T/E) and testosterone/luteinizing hormone (T/LH) ratios. The T/LH ratio is crucial for detecting testosterone and human chorionic gonadotrophin (HCG) use, especially when T/E ratios are altered.

Area of Science:

  • Endocrinology
  • Sports Science
  • Analytical Chemistry

Background:

  • Testosterone administration is a concern in sports and clinical settings.
  • Accurate detection methods are essential for monitoring testosterone use.
  • Urinary ratios of testosterone to epitestosterone (T/E) and luteinizing hormone (T/LH) are potential biomarkers.

Purpose of the Study:

  • To develop and validate a radioimmunoassay method for detecting testosterone administration.
  • To compare the effectiveness of T/E and T/LH ratios in detecting exogenous testosterone and human chorionic gonadotrophin (HCG).
  • To assess the impact of exercise on these urinary ratios.

Main Methods:

  • Radioimmunoassay (RIA) was employed to measure urinary T/E and T/LH ratios.
  • Studies involved intramuscular injections of testosterone heptanoate and HCG in normal men.

Related Experiment Videos

  • Epitestosterone antiserum specificity was evaluated and improved.
  • The effect of exercise on urinary ratios was investigated.

    • Main Results:

    • Both T/E and T/LH ratios effectively detected testosterone administration.
    • The T/LH ratio also indicated HCG use due to antiserum cross-reactivity.
    • Improved epitestosterone antiserum demonstrated insignificant effects of exercise on T/E and T/LH ratios.
    • Combined testosterone/epitestosterone heptanoate injections raised T/LH but not T/E ratios.

    Conclusions:

    • Urinary T/LH ratio is a more robust marker than T/E for detecting testosterone administration, particularly when T/E ratios are manipulated.
    • The T/LH ratio serves as a valuable indicator for both testosterone and HCG administration.
    • The developed RIA method provides a reliable tool for doping control and clinical monitoring.