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Related Experiment Video

Updated: Jun 7, 2026

Fruit Volatile Analysis Using an Electronic Nose

Fruit Volatile Analysis Using an Electronic Nose

Published on: March 30, 2012

A dangerous fruit juice.

Sergio Agosti¹, Laura Casalino, Giovanni Bertero

¹Department of Cardiology, University of Genoa School of Medicine, Genoa, Italy. agostisergio@virgilio.it

The American Journal of Emergency Medicine

|October 26, 2010

Summary

Grapefruit juice significantly increased amiodarone levels, leading to dangerous heart rhythm problems like torsade de pointes. This case highlights the critical need to consider dietary interactions with medications, especially for patients with cardiac conditions.

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Area of Science:

Cardiology
Clinical Pharmacology
Drug Interactions

Background:

Postprandial syncope and atrial fibrillation are significant clinical concerns.
Amiodarone is a widely used antiarrhythmic drug with a complex pharmacokinetic profile.
Drug-food interactions can alter medication efficacy and safety.

Observation:

A patient developed severe QT prolongation and ventricular arrhythmias, including torsade de pointes, after amiodarone administration.
The patient regularly consumed large quantities of grapefruit juice.
Electrical storm necessitated immediate intervention with cardioversion.

Findings:

Grapefruit juice significantly inhibited amiodarone metabolism.
This drug interaction potentiated amiodarone's proarrhythmic effects, leading to life-threatening arrhythmias.
Elevated amiodarone levels were inferred as the cause of the adverse cardiac events.

Implications:

Clinicians must inquire about grapefruit consumption in patients prescribed amiodarone.
Dietary modifications are crucial for managing patients on amiodarone to prevent adverse drug events.
This case underscores the importance of pharmacovigilance regarding food-drug interactions in cardiovascular therapy.