Related Experiment Video

Updated: Jun 7, 2026

A Catheter-Related Candida albicans Infection Model in Mouse
03:24

A Catheter-Related Candida albicans Infection Model in Mouse

Published on: March 22, 2024

Candiduria in renal transplant recipients: incidence, clinical repercussion, and treatment indication

J Delgado1, N Calvo, A Gomis

  • 1Nephrology Department, Hospital Clínico San Carlos, Madrid, Spain. jdelgadodominguez@gmail.com

Transplantation Proceedings
|October 26, 2010
PubMed
Abstract

Insights

Treating candiduria in renal transplant recipients is not necessary. Antifungal therapy did not reduce recurrence or lead to resistant Candida species, with no significant clinical repercussions observed.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • The incidence and management of candiduria in renal transplant recipients are not well-defined.
  • Current antifungal treatment guidelines lack clarity, posing challenges in drug selection due to potential resistance, drug interactions with immunosuppressants, and administration route limitations.

Purpose of the Study:

  • To investigate the incidence of candiduria in renal transplant recipients.
  • To evaluate the clinical impact and effectiveness of antifungal treatment in preventing candiduria recurrence.

Main Methods:

  • A 2-year study of 996 renal transplant recipients.
  • Analysis of Candida-positive urine cultures (>50,000 cfu/mL), species, treatment, and clinical factors including fever, hospitalization, bacterial UTI, antibiotic use, and urinary catheter presence.

Main Results:

  • Accumulated incidence of candiduria was 3.4% (83 episodes in 34 patients).
  • Higher incidence observed in women (6.3% vs 1.7%).
  • Antifungal treatment did not significantly reduce recurrence rates (45.5% treated vs 17.4% untreated) and did not select for resistant Candida species. No significant clinical repercussions were noted.

Conclusions:

  • Routine antifungal treatment for candiduria in renal transplant recipients appears unnecessary.
  • Antifungal therapy showed no benefit in reducing recurrence or preventing resistant species development.
  • No significant clinical repercussions were associated with candiduria in this patient cohort.

More Related Videos

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Trichomoniasis01:18

Trichomoniasis

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.