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Related Concept Videos

Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
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A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
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Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Cryptococcal retropharyngeal abscess.

Rituparna Das1, Kenneth L Muldrew, William E Posligua

  • 1Yale University School of Medicine, Department of Internal Medicine, Section of Infectious Disease, 333 Cedar Street PO Box 208022, New Haven, CT 06520, USA. Rita.Das@yale.edu

Travel Medicine and Infectious Disease
|October 26, 2010
PubMed
Summary
This summary is machine-generated.

Cryptococcus neoformans, a fungal pathogen, caused a retropharyngeal abscess in an immunosuppressed patient with sarcoidosis. Diagnosis was confirmed via yeast identification and rRNA gene sequencing.

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Medical Mycology

Background:

  • Cryptococcus neoformans is an opportunistic fungal pathogen.
  • It primarily affects immunosuppressed individuals, causing various infections.
  • Sarcoidosis is an inflammatory disease that can impair immune function.

Observation:

  • A patient with sarcoidosis presented with odynophagia and a large retropharyngeal abscess.
  • Clinical examination revealed symptoms suggestive of a deep neck infection.

Findings:

  • Aspiration of the abscess yielded budding yeast.
  • Cultures identified the causative agent as Cryptococcus neoformans.
  • D2 large subunit rRNA gene sequencing confirmed the fungal identification.

Implications:

  • This case highlights a rare presentation of cryptococcosis in an immunocompromised patient.
  • Early diagnosis and appropriate antifungal therapy are crucial for managing such infections.
  • Understanding the spectrum of C. neoformans infections is important for clinicians treating immunocompromised populations.