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Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Termination of Translation01:44

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
Termination of Translation01:44

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
Transcription Attenuation in Prokaryotes02:42

Transcription Attenuation in Prokaryotes

Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure.  Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...

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Related Experiment Video

Updated: Jun 7, 2026

Analysis of Termination of Transcription Using BrUTP-strand-specific Transcription Run-on (TRO) Approach
12:12

Analysis of Termination of Transcription Using BrUTP-strand-specific Transcription Run-on (TRO) Approach

Published on: March 12, 2017

WebGeSTer DB--a transcription terminator database.

Anirban Mitra1, Anil K Kesarwani, Debnath Pal

  • 1Department of Microbiology Cell Biology, Indian Institute of Science and Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.

Nucleic Acids Research
|October 26, 2010
PubMed
Summary
This summary is machine-generated.

WebGeSTer DB is the largest database of bacterial intrinsic transcription terminators, offering insights into gene regulation. This resource reveals termination as a conserved and efficient mechanism across bacteria.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Transcription termination is a critical regulatory mechanism in bacteria.
  • Understanding intrinsic terminators is key to deciphering gene expression control.

Purpose of the Study:

  • To present WebGeSTer DB, the most extensive database of bacterial intrinsic transcription terminators.
  • To provide tools for analyzing terminator distribution and characteristics across bacterial genomes.

Main Methods:

  • Identification of approximately one million terminators from 1060 bacterial genomes and 798 plasmids.
  • Development of an interactive platform for data retrieval, visualization, and analysis.
  • Comparative analysis of terminators at whole-genome and gene-specific levels.

Main Results:

  • WebGeSTer DB contains over a million identified intrinsic terminators.
  • The database offers graphical and tabular results with customizable parameters and tiered retrieval.
  • An interactive genome map visualizes terminator distribution.

Conclusions:

  • Intrinsic termination is a highly conserved and efficient regulatory mechanism in bacteria.
  • The database provides valuable insights into the prevalence and role of terminators across diverse bacterial phyla.
  • WebGeSTer DB is freely accessible to the scientific community.