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Related Experiment Video

Updated: Jun 7, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Tissue microarrays and digital image analysis.

Denise Ryan1, Laoighse Mulrane, Elton Rexhepaj

  • 1UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin, Ireland.

Methods in Molecular Biology (Clifton, N.J.)
|October 26, 2010
PubMed
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Tissue microarrays (TMAs) are valuable for high-throughput pathology. This study details the creation of TMAs from rat liver and kidney tissues for toxicology research within the PredTox project.

Area of Science:

  • Toxicology
  • Pathology
  • Biomedical Research

Background:

  • Tissue microarrays (TMAs) are established tools for high-throughput pathological assessment, particularly in cancer research.
  • The application of TMAs in toxicology is less developed, representing a gap in current research methodologies.

Purpose of the Study:

  • To describe the creation of TMAs from rat liver and kidney tissues for toxicology studies.
  • To establish an online resource of histopathological data from these TMAs.

Main Methods:

  • Construction of TMAs using full face sections of liver and kidney from rats treated with drug candidates.
  • Digital slide scanning of kidney and liver sections for creating a digital pathology resource.

Main Results:

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Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas
09:08

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Published on: May 31, 2012

Related Experiment Videos

Last Updated: Jun 7, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas
09:08

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas

Published on: May 31, 2012

  • Successfully created TMAs representative of samples from conventional toxicology studies.
  • Developed a process for digital slide scanning of tissue sections.

Conclusions:

  • TMAs are a viable technology for advancing toxicological studies.
  • The developed TMAs and digital resource can support high-throughput toxicological assessments and predictive toxicology research.