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Updated: Jun 7, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Theoretical investigation of the rubicordifolin cascade
Jean-Philip Lumb1, Jamin L Krinsky, Dirk Trauner
1Department of Chemistry, University of California, Berkeley, California 94720, United States. jplumb@stanford.edu
Abstract:
The results of a theoretical investigation on the complex cascade reaction leading to the natural product rubicordifolin are reported. These computations analyze the discrete transformations that are required during the conversion of the vinyl naphthoquinone starting material into the natural product, including two pseudopericyclic cyclizations as well as a diastereoselective, hetero-Diels-Alder reaction.
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