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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Arteries of Lower Limbs01:20

Arteries of Lower Limbs

The external iliac artery transitions out of the body cavity, entering the femoral region of the lower leg, and is renamed the femoral artery at the point where it traverses the body wall. This artery is responsible for the distribution of blood to the thigh's deep muscles and the skin's ventral and lateral regions, achieved through several minor branches and the lateral deep femoral artery, which also spawns a lateral circumflex artery. The knee area receives blood from the genicular artery,...
Veins of Lower Limbs01:15

Veins of Lower Limbs

The human body consists of an intricate network of veins responsible for the crucial task of blood drainage from the lower limbs. These veins can be categorized into two main types: deep veins and superficial veins.
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Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Cross-bridge Cycle01:26

Cross-bridge Cycle

As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.

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Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration
10:37

Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration

Published on: June 9, 2023

Diffuse lower limb lipoatrophy.

Diana Camacho1, Ursula Pielasinski, Juan María Revelles

  • 1Department of Dermatology, Fundación Jiménez, Universidad Autónoma, Madrid, Spain.

Journal of Cutaneous Pathology
|October 27, 2010
PubMed
Summary
This summary is machine-generated.

Lipoatrophic panniculitis involves subcutaneous fat atrophy. A rare case presented with diffuse, symmetrical lower limb lipoatrophy following an inflammatory process, confirmed by histopathology.

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Area of Science:

  • Dermatology
  • Pathology

Background:

  • Lipoatrophic panniculitis is characterized by subcutaneous fat atrophy.
  • It can be primary (idiopathic) or secondary to various conditions.

Observation:

  • A 76-year-old female experienced diffuse, symmetric lipoatrophy of the lower limbs.
  • This occurred after an extensive inflammatory process affecting thighs to ankles.

Findings:

  • Histopathology revealed lobular panniculitis.
  • Key findings included lymphohistiocytic infiltrate, foamy macrophages, and lipophagic granuloma formation.

Implications:

  • This case highlights a rare presentation of lipoatrophic panniculitis.
  • The diffuse inflammatory process leading to symmetrical lipoatrophy is a notable clinical feature.