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Updated: Jun 7, 2026
Examining BCL-2 Family Function with Large Unilamellar Vesicles
Published on: October 5, 2012
Study of the immunoexpression of Bcl-2 by a cutaneous granular cell tumor
A Fernandez-Flores1, S Valerdiz
1S. Patología Celular, Clinica Ponferrada, Avenida Galicia 1, Ponferrada, Spain. gpyauflowerlion@terra.es
Background:
Cutaneous granular cell tumors have only rarely been examined for Bcl-2, a marker that is expressed by granular cell tumors from other parts of the body.
Objective:
We retrospectively studied three cases of cutaneous granular tumors from our archives.
Methods:
We immunohistochemically tested for neuron-specific enolase (NSE), CD68 (KP1), Bcl-2, and S-100. In Cases 1 and 3, we also tested for CD34, HMB-45, and melan-A. In Case 3, we additionally tested for smooth muscle actin, CD68-PGM1, cytokeratin AE1-AE3, epithelial membrane antigen, desmin, CD1a, and CD117.
Results:
None of our cases presented any of the histological markers traditionally considered to be indicators of potential malignancy in granular cell tumors. All cases strongly expressed S-100, CD68, NSE, and Bcl-2. Case 3 also expressed CD68-PGM1. The rest of the markers were not expressed by the tumors.
Conclusions:
Bcl-2 is expressed by cutaneous granular cell tumors.
