Related Experiment Video
Updated: Jun 7, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Widespread vesiculobullous eruption in a 16-year-old male
1Institute of Pathology, Medical Faculty, University of Ljubljana, Korytkova 2, Ljubljana, Slovenia. joze.pizem@mf.uni-lj.si.
Abstract:
Bullous systemic lupus erythematosus (BSLE) is a rare but distinct disease, characterized by vesiculobullous skin eruptions and systemic lupus erythematosus (SLE). It can arise either before or after a diagnosis of SLE has been established. BSLE is characterized by a dermatitis herpetiformis-like histology and an autoimmunity to type VII collagen. It must be differentiated from other autoimmune vesiculobullous diseases such as epidermolysis bullosa acquisita, dermatitis herpetiformis, linear IgA disease, and bullous pemphigoid. A combination of clinical, histological, and immunofluorescence findings are necessary to establish a diagnosis of BSLE. We present a case of BSLE to illustrate and emphasize the need for an integrative diagnostic approach.
Related Concept Videos
Acne Infection
Smallpox
Genital Herpes
Chickenpox
Rocky Mountain Spotted Fever
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...