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Graham-Little syndrome
B Zegarska1, D Kallas, R A Schwartz
1Department of Cosmetology of Medical University in Bydgoszcz.
Graham-Little syndrome, a rare form of lichen planopilaris, presents with scalp scarring, skin bumps, and hair loss in specific areas. This case highlights prominent scalp symptoms unresponsive to standard treatment.
Area of Science:
- Dermatology
- Trichology
Background:
- Graham-Little syndrome (GLS), or Graham-Little-Piccardi-Lassueur syndrome, is an uncommon variant of lichen planopilaris.
- It typically manifests as cicatricial (scarring) alopecia of the scalp, keratosis pilaris on the trunk/extremities, and non-cicatricial hair loss of the pubic and axillary regions.
Observation:
- A 47-year-old female patient presented with a unique clinical presentation of GLS.
- Her case was notable for a significant prominence of scalp-related findings.
Findings:
- Treatment involved topical steroids and oral prednisone (30 mg daily).
- While systemic treatment improved skin texture, it did not affect the scalp alopecia.
Implications:
- This case underscores the variable clinical presentation of Graham-Little syndrome.
- It suggests that scalp findings in GLS may exhibit resistance to conventional therapies, necessitating further research into alternative or adjunctive treatments.
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