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Diagnosis-specific systemic inflammatory responses to narrowband UVB phototherapy: evidence from hemogram-derived
Efe Görkem Apaydın1, Seçil Soylu2, Yeşim Akpınar Kara1
1Department of Dermatology, SBÜ Ankara Training and Research Hospital, Ankara, Turkey.
Introduction:
Narrowband ultraviolet B (NB-UVB) phototherapy is widely used for inflammatory dermatoses and selected cutaneous lymphomas. Beyond its local skin effects, NB-UVB may also induce systemic immunomodulatory changes. Hemogram-derived indices, including the systemic inflammatory index (SII) and neutrophil-to-lymphocyte ratio (NLR), are practical markers of systemic inflammation.
Methods:
This multicenter retrospective cohort study included 46 patients treated with NB-UVB phototherapy for psoriasis, mycosis fungoides (MF), prurigo nodularis, or other inflammatory dermatoses. Complete blood count parameters obtained before treatment and after 8 to 10 weeks were used to calculate SII and NLR. Biomarker changes were analyzed in the overall cohort and diagnostic subgroups.
Results:
Overall, NB-UVB did not significantly change SII or NLR (p = 0.409 and p = 0.756, respectively). Subgroup analyses demonstrated numerical differences among diagnostic groups. MF demonstrated the greatest numerical reductions in mean SII and NLR, decreasing by 26.05% and 18.58%, respectively, although without statistical significance (p = 0.138 and p = 0.345). Psoriasis showed modest non-significant reductions, whereas prurigo nodularis showed non-significant increases. Percentage changes in SII and NLR were strongly correlated (Spearman's rho = 0.869, p < 0.001). CRP remained stable (p = 0.939).
Conclusions:
NB-UVB did not significantly alter systemic inflammatory indices overall, but subgroup-specific response patterns, particularly in MF, suggest possible diagnosis-specific numerical trends.
