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Drug-induced aseptic meningitis, sensorineural hearing loss and vestibulopaty

Juraj Sepcić1, Mira Bucuk, Olivio Perković

  • 1School of Medicine, Rijeka University, Rijeka, Croatia.

Collegium Antropologicum
|October 28, 2010
PubMed

Insights

Rare adverse drug reactions, including aseptic meningitis and hearing loss, occurred after taking ranitidine, ibuprofen, and ciprofloxacin together. These serious events may be linked to hypersensitivity, with predisposing factors like recurrent infections and allergies.

Area of Science:

  • Pharmacology
  • Neurology
  • Otolaryngology

Background:

  • Investigating rare adverse drug reactions (ADRs) from co-administered medications.
  • Identifying potential predisposing factors for severe ADRs.

Observation:

  • A patient experienced aseptic meningitis and sensorineural hearing loss, tinnitus, and vestibulopathy after receiving ranitidine, ibuprofen, and ciprofloxacin.
  • Predisposing factors included recurrent urinary tract infections, familial migraine, and allergies to trimethoprim-sulfamethoxazole and chromium.

Findings:

  • A close temporal relationship was observed between drug administration, particularly ibuprofen, and the onset of adverse reactions.
  • Infection and autoimmune diseases were ruled out as causes for the observed symptoms.

Implications:

  • The study suggests a hypersensitivity reaction affecting the meninges and cochlea as a potential mechanism for these severe ADRs.
  • Highlights the importance of considering drug interactions and patient history in managing adverse events.

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