Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Applicability of methylliberine as a salivary marker under postprandial conditions.

International journal of pharmaceutics: X·2026
Same author

Hydrogel Vehicles for Enteric-Coated Pantoprazole Minitablets: Impact of Polymer Type on Rheology and Drug Release.

Gels (Basel, Switzerland)·2026
Same author

Evidence for the existence of the <i>Magenstrasse</i> and the <i>Darmstrasse</i> when ingesting a caloric solution after a solid meal: A MRI study.

International journal of pharmaceutics: X·2026
Same author

Comparative <i>In Vitro</i> Release Profiling of Brand and Generic Metoprolol Extended-Release Formulations in the Context of Product Switching.

Die Pharmazie·2026
Same author

Isocaloric liquid and solid meals induce comparable postprandial gastric motility: Implications for oral drug delivery assessed by real-time MRI.

International journal of pharmaceutics: X·2026
Same author

From the Proteome to Therapeutics: A Multi-Database Approach to Drug Discovery in Periodontitis-An Exploratory Pilot Study.

Journal of clinical periodontology·2026
Same journal

Dry powder inhaler selection in COPD: integrating device design, formulation performance, and patient inspiratory capability.

Expert opinion on drug delivery·2026
Same journal

Letter to the Editor: 'saving money but costing lives: the lack of integrated dose counters on pressurised metered dose inhalers'.

Expert opinion on drug delivery·2026
Same journal

Response to letter to the editor: 'Saving money but costing lives: the lack of integrated dose counters on pressurised metered dose inhalers'.

Expert opinion on drug delivery·2026
Same journal

Mechanism-guided metal complex therapeutics for biofilm-driven wound infections and transdermal delivery.

Expert opinion on drug delivery·2026
Same journal

Next-generation strategies for PROTAC formulation: mechanistic insights and advanced formulation technologies.

Expert opinion on drug delivery·2026
Same journal

Drug penetration in solid tumors: influence of drug size and capillary architecture.

Expert opinion on drug delivery·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2026

Stress-induced Antibiotic Susceptibility Testing on a Chip
12:41

Stress-induced Antibiotic Susceptibility Testing on a Chip

Published on: January 8, 2014

A biorelevant dissolution stress test device - background and experiences.

Grzegorz Garbacz1, Sandra Klein, Werner Weitschies

  • 1University of Greifswald, Institute of Pharmacy, Friedrich-Ludwig-Jahn-Strasse 17, Greifswald, Germany. grzegorz.garbacz@uni-greifswald.de

Expert Opinion on Drug Delivery
|October 28, 2010
PubMed
Summary
This summary is machine-generated.

A new dissolution test apparatus simulates gastrointestinal conditions to better predict drug release from modified release (MR) dosage forms. This helps identify dosage forms sensitive to mechanical stress, preventing issues like dose dumping.

More Related Videos

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation
09:48

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

Published on: June 2, 2022

A Testing Platform for Durability Studies of Polymers and Fiber-reinforced Polymer Composites under Concurrent Hygrothermo-mechanical Stimuli
07:15

A Testing Platform for Durability Studies of Polymers and Fiber-reinforced Polymer Composites under Concurrent Hygrothermo-mechanical Stimuli

Published on: December 11, 2014

Related Experiment Videos

Last Updated: Jun 7, 2026

Stress-induced Antibiotic Susceptibility Testing on a Chip
12:41

Stress-induced Antibiotic Susceptibility Testing on a Chip

Published on: January 8, 2014

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation
09:48

A Friction Testing-Bioreactor Device for Study of Synovial Joint Biomechanics, Mechanobiology, and Physical Regulation

Published on: June 2, 2022

A Testing Platform for Durability Studies of Polymers and Fiber-reinforced Polymer Composites under Concurrent Hygrothermo-mechanical Stimuli
07:15

A Testing Platform for Durability Studies of Polymers and Fiber-reinforced Polymer Composites under Concurrent Hygrothermo-mechanical Stimuli

Published on: December 11, 2014

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Biopharmaceutics

Background:

  • Accurate prediction of in vivo drug release from modified release (MR) oral dosage forms using in vitro dissolution tests is crucial for successful product development.
  • Current dissolution testing methods may not fully capture the complex physical conditions within the gastrointestinal (GI) tract.

Purpose of the Study:

  • To introduce a novel dissolution test apparatus designed to simulate the physical forces encountered during gastrointestinal transit of MR dosage forms.
  • To enhance the predictive accuracy of in vitro dissolution testing for MR oral dosage forms.

Main Methods:

  • Development of a new dissolution test apparatus simulating GI physical conditions, including pressure, shear stress, and intermittent fluid contact.
  • Evaluation of the apparatus using extended release (ER) tablets of nifedipine and diclofenac.
  • Analysis of drug release profiles under simulated GI mechanical stress.

Main Results:

  • The new apparatus successfully simulated key physical conditions of the GI passage, such as pressure and shear stress.
  • Dissolution characteristics of tested ER products were significantly influenced by the simulated mechanical stress.
  • Sensitivity of dosage forms to GI-specific physical conditions was identified as a potential cause of irregular drug release and dose dumping.

Conclusions:

  • The developed dissolution test apparatus provides a more biorelevant assessment of MR dosage form performance.
  • Understanding dosage form sensitivity to mechanical stress is vital for preventing in vivo performance variability and ensuring predictable drug plasma concentrations.
  • This approach aids in identifying potential issues like dose dumping early in product development.