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A Quantitative Detection Method for MicroRNAs in the Kidney of an Ischemic Kidney Injury Mouse Model
Published on: September 11, 2020
Biomarkers of impaired renal function
Frank A Post1, Christina M Wyatt, Amanda Mocroft
1King's College London School of Medicine, London, UK.
Current Opinion in HIV and AIDS
|October 28, 2010
Summary
Monitoring kidney function in HIV patients is crucial. This review highlights recent findings on renal biomarkers, including creatinine, cystatin C, and tubular markers, to improve detection and management of kidney disease in this population.
Area of Science:
- Nephrology
- Infectious Diseases
- HIV Medicine
Background:
- Renal disease is a growing concern in the aging HIV-infected population.
- Current renal function monitoring tools lack established validation in HIV.
- This review synthesizes recent advancements in renal biomarker research for HIV.
Purpose of the Study:
- To review current and emerging biomarkers for renal function assessment in HIV.
- To discuss the utility and limitations of various biomarkers in HIV-infected individuals.
- To inform clinical practice regarding optimal renal monitoring strategies in HIV.
Main Methods:
- Literature review of recent studies on renal biomarkers in HIV.
- Analysis of creatinine-based estimations, cystatin C, proteinuria, albuminuria, and tubular markers.
- Evaluation of biomarker performance in detecting renal dysfunction and adverse outcomes.
Main Results:
- Creatinine-based glomerular filtration rate estimations are not validated in HIV.
- Serum cystatin C shows promise but may reflect inflammation.
- Proteinuria and albuminuria screening identify high-risk patients; tubular markers like RBP, β2M, and NGAL are studied for tenofovir-associated Fanconi syndrome and subclinical tubular dysfunction.
Conclusions:
- Optimal biomarkers for renal disease detection and monitoring in HIV require further investigation.
- Future research should focus on validating and comparing biomarkers in diverse HIV populations.
- Establishing consensus on biomarker application is essential for effective renal care in HIV.
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