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[Bax and TGFβRII frameshift mutations in lung cancer]
1Department of Respiratory Diseases,The Second Affiliated Hospital,Xi'an Medical University,Xi'an,Shanxi 710004,P.R.China.
Background:
To explore frameshift mutations in the Bax and TGFβRII genes and the relationship between frameshift mutations and microsatellite alterations in lung cancer.
Methods:
Frameshift mutations and microsatellite alterations were detected in 50 primary lung cancer tissues by PCR,8% denature polyacrylamide gel electrophoresis and silver staining.
Results:
Bax gene (G)₈ frameshift mutations were detected in 12 cases (24%，12/50),and all were base deletion mutations.Bax frameshift mutations correlated with microsatellite alterations (P<0.05).TGFβRII (A)₁₀ frameshift mutations were not found.
Conclusions:
Bax gene frameshift mutations are found in lung cancer,and closely correlate with microsatellite alterations.Bax gene and microsatellite might play a certain role in carcinogenesis of lung cancer.
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