Related Experiment Video
Updated: Sep 15, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
[Caffey's disease]
F Femiano1, S Cozzolino, A Malzone
1Università degli Studi di Napoli.
Insights
Caffey's disease, also known as infantile cortical hyperostosis, is a rare condition in infants under five months. It presents as acute febrile illness with painful bone swellings and inflammation.
Area of Science:
- Pediatrics
- Neonatology
- Skeletal Dysplasias
Context:
- Infantile cortical hyperostosis, known as Caffey's disease, is a rare neonatal disorder.
- Characterized by specific clinical and radiographic findings.
- Primarily affects infants within the first five months of life.
Purpose:
- To describe the typical presentation and key features of Caffey's disease.
- To highlight the diagnostic challenges and clinical course.
- To inform pediatricians and healthcare providers about this rare condition.
Summary:
- Caffey's disease manifests as an acute febrile illness in infants.
- Accompanied by painful, subperiosteal soft tissue swellings over affected bones.
- Exhibits signs consistent with acute inflammation.
Impact:
- Facilitates earlier recognition and diagnosis of infantile cortical hyperostosis.
- Aids in differentiating Caffey's disease from other pediatric bone disorders.
- Improves management strategies for affected infants.
Abstract:
Caffey's disease or infantile cortical hyperostosis a rare condition affecting infants in the first five months of life. The disease begins usually as an acute febrile illness accompanied by painful swellings over one or more bones, with all the signs of acute inflammation.
More Related Videos
05:14Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography
Published on: August 11, 2023
05:56Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
Related Concept Videos
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Cryptococcal Meningitis
Cushing Syndrome I: Introduction
Cushing Syndrome II: Pathophysiology
Hepatic Encephalopathy