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Related Experiment Videos

Visual neglect during intracarotid amobarbital testing.

P A Spiers1, D L Schomer, H W Blume

  • 1Clinical Research Center, Massachusetts Institute of Technology, Cambridge 02142.

Neurology
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

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Sodium amobarbital temporarily suppresses brain hemisphere function, potentially causing visual neglect. This study found right-hemisphere suppression, particularly in the frontal lobe, is linked to attention deficits and scanning impairments.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Hemispatial visual neglect can result from unilateral brain hemisphere suppression.
  • The precise anatomical basis for directed attention to extrapersonal space requires further elucidation.

Purpose of the Study:

  • To investigate the link between sodium amobarbital-induced hemispheric suppression and hemispatial visual neglect.
  • To identify the specific brain regions responsible for directed attention by correlating scanning performance with electroencephalogram (EEG) activity.

Main Methods:

  • Forty-eight epilepsy patients undergoing preoperative intracarotid amobarbital tests.
  • Assessment of scanning performance using a random letter cancellation task.
  • Correlation of scanning performance with EEG activity during hemisphere suppression.

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Main Results:

  • Disruption of scanning and contralateral neglect occurred exclusively after right-hemisphere suppression.
  • These deficits were specifically associated with changes in right frontal lobe EEG activity.
  • The observed pattern persisted across right-handed, left-handed, and right-hemisphere language-dominant individuals.

Conclusions:

  • The right hemisphere, particularly the frontal lobe, plays a critical role in directed attention to extrapersonal space.
  • Sodium amobarbital testing can reveal hemispheric contributions to visual neglect and attention.
  • Findings are consistent regardless of handedness or language dominance.