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Updated: Jun 7, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
Published on: August 15, 2018
Design and synthesis of threading intercalators to target DNA
Lesley A Howell1, Rosul Gulam, Anja Mueller
1School of Pharmacy, University of East Anglia, Norwich, United Kingdom.
Abstract:
Threading intercalators are high affinity DNA binding agents that bind by inserting a chromophore into the duplex and locating one group in each groove. The first threading intercalators that can be conjugated to acids, sulfonic acids and peptides to target them to duplex DNA are described, based upon the well studied acridine-3- or 4-carboxamides. Cellular uptake of the parent acridine is rapid and it can be visualized in the nucleus of cells. Both the parent compounds and their conjugates maintain antitumor activity.
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