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[Changes in systemic circulation under induced total spinal block and choice of vasopressors]
M Kobori1, H Negishi, Y Masuda
1Department of Anesthesiology, School of Medicine, Showa University, Tokyo.
Masui. the Japanese Journal of Anesthesiology
|December 1, 1990
Abstract:
Total spinal block by using 2% lidocaine 0.5 ml.kg-1 (10.0 mg.kg-1) was carried out in adult mongrel dogs. The effects of atropine 0.02 mg.kg-1, isoproterenol 0.5 mcg.kg-1, methoxamine 0.1 mg.kg-1 and ephedrine 0.5 mg.kg-1 to counteract circulatory changes by total spinal block were studied. Atropine did not exert any marked influence on circulatory system. Isoproterenol elevated HR, LV dp/dt max and CI temporarily, but did not decrease MAP and SVR. Methoxamine elevated MAP and SVR, but decreased CI. Ephedrine is a drug of choice for this situation because it elevated HR, MAP, LV dp/dt max and SVR.