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Published on: April 27, 2017
Synthesis and preliminary pharmacological assessment of novel gamma-hydroxybutyric acid derivatives
D Malec1, J Modzelewski, B Malawska
1Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
Abstract:
Synthesis and properties of new N-substituted amides of alpha-(1,1-ethylenedioxy)-ethyl-gamma-hydroxybutyric acid are described. The compounds were obtained by aminolysis of 3-(1,1-ethylenedioxy)-ethyltetra-hydrofuran-2-on with primary alkylarylamines. Preliminary pharmacological assessment revealed that the compounds exert weaker influence on the central nervous system than the reference gamma-hydroxybutyric acid. Three of the novel compounds offered some protection against pentetrazole-induced tonic seizures in mice.
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