Fibrinolytic activity of human brain

Authors studied the fibrinolytic human brain activity using the fibrin film in order to determine the location of tissue plasminogen activators. An amount of 20 human brains has been evaluated issued from cadavers with no signs of cerebral disease when alive. Most high concentration of plasminogen activators was evidenced in samples from plexus chorioideus and pia mater, while the fibrinolytic activity of grey and white matter showed uniformly low values. Large amount of plasminogen activators may be released into cerebro-spinal fluid, what can lead to a rapid fibrin clot dissolution around the aneurysm, so the rebleed may be consequential to it.