Immunosorbents based on uncoated synthetic charcoals: preparation, properties, applications

By means of water-soluble carbodiimide coupling technique various bioligands were covalently attached to the surface of uncoated synthetic active carbons and a number of sorbents with certain biological functions were thus designed. Carbonaceous sorbents with immobilized ligands demonstrate increased affinity towards specific sorbates compared to that of starting matrix. As soon as SCN and SCS synthetic carbons are used uncoated they can be highly loaded with protein molecules - up to 80 mg serum albumin, 6-10 mg IgG rabbit etc. per gram of sorbent. Carbonaceous immunosorbents retain biocompatibility and substantial non-specific adsorptive capacity of initial hemosorbents. A conclusion is drawn that uncoated synthetic charcoals can serve a basis for design of selective hemosorbents intended for solving complicated problems of immunocorrection.