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Published on: June 2, 2015
[Wilson's disease: computed tomography and magnetic resonance imaging]
J Tejada1, P Barreiro, E Díez Tejedor
1Servicio de Neurología, Hospital La Paz, Universidad Autónoma, Madrid.
Neurologia (Barcelona, Spain)
|November 1, 1990
Summary
Wilson's disease (WD) involves reduced copper excretion, leading to toxic buildup. Neuroimaging like CT and NMR effectively visualize CNS lesions characteristic of this genetic disorder.
Area of Science:
- Neurology
- Medical Imaging
- Genetics
Background:
- Wilson's disease is an inherited disorder affecting copper metabolism.
- Impaired biliary copper excretion causes toxic accumulation in organs, including the brain.
Observation:
- Computed tomography (CT) and nuclear magnetic resonance (NMR) are used for diagnosing suspected Wilson's disease.
- Two patients with Wilson's disease underwent CT and NMR for central nervous system (CNS) evaluation.
Findings:
- CT revealed hypodense lesions, while NMR showed signal abnormalities in the putamen, caudate nucleus, cerebellar dentate nucleus, red nucleus, and white matter.
- NMR T2-weighted images displayed hypointense signals in the putamen, potentially indicating necrosis or copper deposition.
- Lesion patterns suggest vascular involvement in Wilson's disease pathogenesis.
Implications:
- CT and NMR are valuable tools for assessing CNS involvement in Wilson's disease.
- NMR imaging provides characteristic findings for diagnosing Wilson's disease.
- Understanding neuroimaging findings aids in the diagnosis and management of Wilson's disease.
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