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The influence of ethanol on the distribution of amitriptyline and nortriptyline in rats
A Negrusz1, J Brandys, W Piekoszewski
1Toxicological Department, Medical Academy Cracov, Kraków, Poland.
Die Pharmazie
|November 1, 1990
Abstract:
The influence of ethanol in single and multiple doses on concentration-time profile of amitriptyline (1) and nortriptyline (2) in rat serum, brain, heart, and liver was studied. AUC0-6 values were calculated and statistically compared as well as cmax values in serum and tissues. Ethanol inhibited N-demethylation of 1 and therefore 2 has not been detected in biological material. AUC0-6 and cmax values were less than in control group. All AUC0-6 and cmax values for 1 in ethanol treated groups of rats were statistically significant compared with the control group.